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Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway

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168 A large meta-analysis of 65 randomized controlled trials with 7,887 hypertensive subjects found folic acid plus blood pressure-lowering medication was more effective than medication alone for lowering blood pressure, lowering homocysteine levels, and reducing risk of cardiovascular events and stroke by 13% compared with control groups

Results persist but gradually return toward baseline without ongoing support

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